Mimicking the Biological Sense of Taste In Vitro Using a Taste Organoids-on-a-Chip System.

ABSTRACT: Thanks to the gustatory system, humans can experience the flavors in foods and drinks while avoiding the intake of some harmful substances. Although great advances in the fields of biotechnology, microfluidics, and nanotechnologies have been made in recent years, this astonishing recognition system can hardly be replaced by any artificial sensors designed so far. Here, taste organoids are coupled with an extracellular potential sensor array to form a novel bioelectronic organoid and developed a taste organoids-on-a-chip system (TOS) for highly mimicking the biological sense of taste ex vivo with high stability and repeatability. The taste organoids maintain key taste receptors expression after the third passage and high cell viability during 7 days of on-chip culture. Most importantly, the

SUBMITTER: Wu J 

PROVIDER: S-EPMC9982573 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature