Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment.

ABSTRACT: High levels of reactive oxygen species (ROS) and inflammation create a complicated extrinsic neural environment that dominates the initial post-injury period after spinal cord injury (SCI). The compensatory pathways between ROS and inflammation limited the efficacy of modulating the above single treatment regimen after SCI. Here, novel "nanoflower" Mn₃ O₄ integrated with "pollen" ^IRF-5 SiRNA was designed as a combination antioxidant and anti-inflammatory treatment after SCI. The "nanoflower" and "pollen" structure was encapsulated with a neutrophil membrane for protective and targeted delivery. Furthermore, valence-engineered nanozyme Mn₃ O₄ imitated the cascade response of antioxidant enzymes with a higher substrate affinity compared

SUBMITTER: Xiong T 

PROVIDER: S-EPMC9982579 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature