Deep Eutectic Solvents for Subcutaneous Delivery of Protein Therapeutics.

ABSTRACT: Proteins are among the most common therapeutics for the treatment of diabetes, autoimmune diseases, cancer, and metabolic diseases, among others. Despite their common use, current protein therapies, most of which are injectables, have several limitations. Large proteins such as monoclonal antibodies (mAbs) suffer from poor absorption after subcutaneous injections, thus forcing their administration by intravenous injections. Even small proteins such as insulin suffer from slow pharmacokinetics which poses limitations in effective management of diabetes. Here, a deep eutectic-based delivery strategy is used to offer a generalized approach for improving protein absorption after subcutaneous injections. The lead formulation enhances absorption of mAbs after subcutaneous injections by ≈200%. Th

SUBMITTER: Curreri AM 

PROVIDER: S-EPMC9982585 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature