NADK-mediated de novo NADP(H) synthesis is a metabolic adaptation essential for breast cancer metastasis.

ABSTRACT: Metabolic reprogramming and metabolic plasticity allow cancer cells to fine-tune their metabolism and adapt to the ever-changing environments of the metastatic cascade, for which lipid metabolism and oxidative stress are of particular importance. NADPH is a central co-factor for both lipid and redox homeostasis, suggesting that cancer cells may require larger pools of NADPH to efficiently metastasize. NADPH is recycled through reduction of NADP⁺ by several enzymatic systems in cells; however, de novo NADP⁺ is synthesized only through one known enzymatic reaction, catalyzed by NAD⁺ kinase (NADK). Here, we show that NADK is upregulated in metastatic breast cancer cells enabling de novo production of NADP(H) and the expansion of the NADP(H) pools thereby incre

SUBMITTER: Ilter D 

PROVIDER: S-EPMC9982641 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature