Target attainment and population pharmacokinetics of flucloxacillin in critically ill patients: a multicenter study.

ABSTRACT:

Purpose

Insufficient antimicrobial exposure has been associated with worse clinical outcomes. Reportedly, flucloxacillin target attainment in critically ill patients was heterogeneous considering the study population selection and reported target attainment percentages. Therefore, we assessed flucloxacillin population pharmacokinetics (PK) and target attainment in critically ill patients.

Methods

This prospective, multicenter, observational study was conducted from May 2017 to October 2019 and included adult, critically ill patients administered flucloxacillin intravenously. Patients with renal replacement therapy or liver cirrhosis were excluded. We developed and qualified an integrated PK model for total and unbound serum flucloxacillin concentrations. Monte Carlo dosing s

SUBMITTER: Meenks SD 

PROVIDER: S-EPMC9982780 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature