Anti-inflammatory constituents isolated from the flowers of Hosta plantaginea via suppression of the NF-κB signaling pathway in LPS-stimulated RAW 264.7 macrophages† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2ra07623c

ABSTRACT: Hosta plantaginea (Lam.) Aschers flower is traditionally used in China as an important herbal medicine for the treatment of inflammatory disease. The present study isolated one new compound, namely (3R)-dihydrobonducellin (1), and five known ones, p-hydroxycinnamic acid (2), paprazine (3), thymidine (4), bis(2-ethylhexyl) phthalate (5), and dibutyl phthalate (6) from H. plantaginea flowers. These structures were elucidated from spectroscopic data. Among them, compounds 1–4 remarkably suppressed nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells with half maximal inhibitory concentration (IC50) values of 19.88 ± 1.81, 39.80 ± 0.85, 19.03 ± 2.35, and 34.63 ± 2.38 μM, respectively. Furthermore, compounds 1 and 3 (20 μM) significantly decreased levels of tumor nec

SUBMITTER: He J 

PROVIDER: S-EPMC9982826 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature