Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle.

ABSTRACT: Aging is a multifactorial process associated with progressive degradation of physiological integrity and function. One of the greatest factors contributing to the deleterious effects of aging is the decline of functional ability due to loss of muscle mass, strength, and function, a condition termed sarcopenia. Calorie restriction (CR) has consistently been shown to extend lifespan and delay the onset and progression of various age-related diseases, including sarcopenia. Additional anti-aging interventions that are receiving scientific attention are CR mimetics. Of these pharmacological compounds, rapamycin has shown similar CR-related longevity benefits without the need for diet restrictions. To investigate the potential role of rapamycin as an anti-sarcopenic alternative to CR, we conduct

SUBMITTER: Orenduff MC 

PROVIDER: S-EPMC9982835 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature