Flexible and Implantable Polyimide Aptamer-Field-Effect Transistor Biosensors.

ABSTRACT: Monitoring neurochemical signaling across time scales is critical to understanding how brains encode and store information. Flexible (vs stiff) devices have been shown to improve in vivo monitoring, particularly over longer times, by reducing tissue damage and immunological responses. Here, we report our initial steps toward developing flexible and implantable neuroprobes with aptamer-field-effect transistor (FET) biosensors for neurotransmitter monitoring. A high-throughput process was developed to fabricate thin, flexible polyimide probes using microelectromechanical-system (MEMS) technologies, where 150 flexible probes were fabricated on each 4 in. Si wafer. Probes were 150 μm wide and 7 μm thick with two FETs per tip. The bending stiffness was 1.2 × 10^-11 N·m²

SUBMITTER: Zhao C 

PROVIDER: S-EPMC9982941 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature