Catalyst-Free Aqueous Hyperpolarized [1-¹³C]Pyruvate Obtained by Re-Dissolution Signal Amplification by Reversible Exchange.

ABSTRACT: Despite great successes in oncology, patient outcomes are often still discouraging, and hence the diagnostic imaging paradigm is increasingly shifting toward functional imaging of the pathology to better understand individual disease biology and to personalize therapies. The dissolution Dynamic Nuclear Polarization (d-DNP) hyperpolarization method has enabled unprecedented real-time MRI sensing of metabolism and tissue pH using hyperpolarized [1-¹³C]pyruvate as a biosensor with great potential for diagnosis and monitoring of cancer patients. However, current d-DNP is expensive and suffers from long hyperpolarization times, posing a substantial translational roadblock. Here, we report the development of Re-Dissolution Signal Amplification By Reversible Exchange (Re-D SABRE), whic

SUBMITTER: Schmidt AB 

PROVIDER: S-EPMC9983023 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature