Striatal dopamine supports reward expectation and learning: A simultaneous PET/fMRI study.

ABSTRACT: Converging evidence from both human neuroimaging and animal studies has supported a model of mesolimbic processing underlying reward learning behaviors, based on the computation of reward prediction errors. However, competing evidence supports human dopamine signaling in the basal ganglia as also contributing to the generation of higher order learning heuristics. Here, we present data from a large (N = 81, 18-30yo), multi-modal neuroimaging study using simultaneously acquired task fMRI, affording temporal resolution of reward system function, and PET imaging with [¹¹C]Raclopride (RAC), assessing striatal dopamine (DA) D2/3 receptor binding, during performance of a probabilistic reward learning task. Both fMRI activation and PET DA measures showed ventral striatum involvement for

SUBMITTER: Calabro FJ 

PROVIDER: S-EPMC9983071 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature