Disseminated intravascular coagulation phenotype is regulated by the TRPM7 channel during sepsis.

ABSTRACT: Sepsis is an uncontrolled inflammatory response against a systemic infection that results in elevated mortality, mainly induced by bacterial products known as endotoxins, producing endotoxemia. Disseminated intravascular coagulation (DIC) is frequently observed in septic patients and is associated with organ failure and death. Sepsis activates endothelial cells (ECs), promoting a prothrombotic phenotype contributing to DIC. Ion channel-mediated calcium permeability participates in coagulation. The transient reception potential melastatin 7 (TRPM7) non-selective divalent cation channel that also contains an α-kinase domain, which is permeable to divalent cations including Ca2+, regulates endotoxin-stimulated calcium permeability in ECs and is associated with increased mortality in septic pa

SUBMITTER: Jimenez-Dinamarca I 

PROVIDER: S-EPMC9983216 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature