The ELF3 transcription factor is associated with an epithelial phenotype and represses epithelial-mesenchymal transition.

ABSTRACT:

Background

Epithelial-mesenchymal plasticity (EMP) involves bidirectional transitions between epithelial, mesenchymal and multiple intermediary hybrid epithelial/mesenchymal phenotypes. While the process of epithelial-mesenchymal transition (EMT) and its associated transcription factors are well-characterised, the transcription factors that promote mesenchymal-epithelial transition (MET) and stabilise hybrid E/M phenotypes are less well understood.

Results

Here, we analyse multiple publicly-available transcriptomic datasets at bulk and single-cell level and pinpoint ELF3 as a factor that is strongly associated with an epithelial phenotype and is inhibited during EMT. Using mechanism-based mathematical modelling, we also show that ELF3 inhibits the progression of EMT. This be

SUBMITTER: Subbalakshmi AR 

PROVIDER: S-EPMC9983220 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature