Effects of diabetes on microglial physiology: a systematic review of in vitro, preclinical and clinical studies.

ABSTRACT: Diabetes mellitus is a heterogeneous chronic metabolic disorder characterized by the presence of hyperglycemia, commonly preceded by a prediabetic state. The excess of blood glucose can damage multiple organs, including the brain. In fact, cognitive decline and dementia are increasingly being recognized as important comorbidities of diabetes. Despite the largely consistent link between diabetes and dementia, the underlying causes of neurodegeneration in diabetic patients remain to be elucidated. A common factor for almost all neurological disorders is neuroinflammation, a complex inflammatory process in the central nervous system for the most part orchestrated by microglial cells, the main representatives of the immune system in the brain. In this context, our research question aimed to un

SUBMITTER: Vargas-Soria M 

PROVIDER: S-EPMC9983227 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature