Landscape analysis of m6A modification regulators related biological functions and immune characteristics in myasthenia gravis.

ABSTRACT:

Background

N6-methyladenosine (m6A) modification has been recognized to play fundamental roles in the development of autoimmune diseases. However, the implication of m6A modification in myasthenia gravis (MG) remains largely unknown. Thus, we aimed to systematically explore the potential functions and related immune characteristics of m6A regulators in MG.

Methods

The GSE85452 dataset with MG and healthy samples was downloaded from Gene Expression Omnibus (GEO) database. m6A modification regulators were manually curated. The targets of m6A regulators were obtained from m6A2Target database. The differential expressed m6A regulators in GSE85452 dataset were identified by "limma" package and were validated by RT-PCR. Function enrichment analysis of dysregulated m6A regulators w

SUBMITTER: Li S 

PROVIDER: S-EPMC9983271 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature