Prenatal alcohol exposure results in brain region- and sex-specific changes in circHomer1 expression in adult mouse brain.

ABSTRACT: Circular RNAs (circRNAs) are a novel category of covalently-closed non-coding RNAs mainly derived from the back-splicing of exons or introns of protein-coding genes. In addition to their inherent high overall stability, circRNAs, have been shown to have strong functional effects on gene expression via a multitude of transcriptional and post-transcriptional mechanisms. Furthermore, circRNAs, appear to be particularly enriched in the brain and able to influence both prenatal development and postnatal brain function. However, little is known about the potential involvement of circRNAs in the long term influence of prenatal alcohol exposure (PAE) in the brain and their relevance for Fetal Alcohol Spectrum Disorders (FASD). Using circRNA-specific quantification, we have found that cir

SUBMITTER: Papageorgiou G 

PROVIDER: S-EPMC9983553 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature