Phenotypic pliancy and the breakdown of epigenetic polycomb mechanisms.

ABSTRACT: Epigenetic regulatory mechanisms allow multicellular organisms to develop distinct specialized cell identities despite having the same total genome. Cell-fate choices are based on gene expression programs and environmental cues that cells experience during embryonic development, and are usually maintained throughout the life of the organism despite new environmental cues. The evolutionarily conserved Polycomb group (PcG) proteins form Polycomb Repressive Complexes that help orchestrate these developmental choices. Post-development, these complexes actively maintain the resulting cell fate, even in the face of environmental perturbations. Given the crucial role of these polycomb mechanisms in providing phenotypic fidelity (i.e. maintenance of cell fate), we hypothesize that their dysregulat

SUBMITTER: Lambros M 

PROVIDER: S-EPMC9983867 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature