Stool biomarkers as measures of enteric pathogen infection in infants from Addis Ababa informal settlements.

ABSTRACT: Frequent enteric infections in children may be an important cause of growth faltering; however, we do not fully understand the mechanisms by which pathogen infections and the physiological responses to these infections result in poorer growth. Commonly used protein fecal biomarkers (anti-alpha trypsin, neopterin, and myeloperoxidase) provide broad immunological information on an inflammatory response; however, they do not provide information on non-immune processes (e.g., gut integrity) that may be important indicators of chronic end states such as environmental enteric dysfunction (EED). To explore how additional biomarkers will better inform which physiological pathways (both immune and non-immune) are impacted by pathogen exposure we added to the traditional panel of 3 protein fecal bio

SUBMITTER: Espira LM 

PROVIDER: S-EPMC9983878 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature