Neural adaptation and fractional dynamics as a window to underlying neural excitability.

ABSTRACT: The relationship between macroscale electrophysiological recordings and the dynamics of underlying neural activity remains unclear. We have previously shown that low frequency EEG activity (<1 Hz) is decreased at the seizure onset zone (SOZ), while higher frequency activity (1-50 Hz) is increased. These changes result in power spectral densities (PSDs) with flattened slopes near the SOZ, which are assumed to be areas of increased excitability. We wanted to understand possible mechanisms underlying PSD changes in brain regions of increased excitability. We hypothesized that these observations are consistent with changes in adaptation within the neural circuit. We developed a theoretical framework and tested the effect of adaptation mechanisms, such as spike frequency adaptation and synaptic

SUBMITTER: Lundstrom BN 

PROVIDER: S-EPMC9983885 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature