In Silico Molecular Docking Studies of Phytocompounds From Coleus Amboinicus Against Glucokinase.

ABSTRACT: Diabetes is one of the most prevalent metabolic illnesses that can be fatal, and it is the ninth-largest cause of mortality worldwide. Even though there are effective hypoglycemic medications available for the treatment of diabetes, researchers continue to look for a medication that is more effective and has fewer adverse effects by focusing on various metabolic components such as enzymes, transporters, receptors. The enzyme Glucokinase (GCK), which is present mainly in the liver and beta cells of the pancreas, is involved in maintaining blood glucose homeostasis. Hence, the present in silico study is designed to determine the interaction between GCK and compounds (ligands) of Coleus amboinicus. In the current docking investigation, we discovered that important residues, including A

SUBMITTER: Anthony Ammal SM 

PROVIDER: S-EPMC9984118 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature