The impact of pre-transplant weight loss on survival following cardiac transplantation.

ABSTRACT:

Background

Significant weight loss due to cardiac cachexia is an independent predictor of mortality in many heart failure (HF) clinical trials. The impact of significant weight loss while on the waitlist for heart transplant (HT) has yet to be studied with respect to post-transplant survival.

Methods

Adult HT recipients from 2010 to 2021 were identified in the UNOS registry. Patients who experienced an absolute weight change from the time of listing to transplant were included and classified into two groups by percent weight loss from time of listing to time of transplant using a cut-off of 10%. The primary endpoint was 1-year survival following HT.

Results

5951 patients were included in the analysis, of whom 763 (13%) experienced ≥10% weight loss from the time of lis

SUBMITTER: Driggin E 

PROVIDER: S-EPMC9984247 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature