Association of accelerometer-derived circadian abnormalities and genetic risk with incidence of atrial fibrillation.

ABSTRACT: Evidence suggests potential links between circadian rhythm and atrial fibrillation (AF). However, whether circadian disruption can predict the onset of AF in the general population remains largely unknown. We aim to investigate the association of accelerometer-measured circadian rest-activity rhythm (CRAR, the most prominent circadian rhythm in humans) with the risk of AF, and examine joint associations and potential interactions of CRAR and genetic susceptibility with AF incidence. We include 62,927 white British participants of UK Biobank without AF at baseline. CRAR characteristics, including amplitude (strength), acrophase (timing of peak activity), pseudo-F (robustness), and mesor (height), are derived by applying an extended cosine model. Genetic risk is assessed with polygenic risk

SUBMITTER: Yang L 

PROVIDER: S-EPMC9984286 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature