Quantitative ^99mTc-DPD-SPECT/CT assessment of cardiac amyloidosis.

ABSTRACT:

Introduction

Transthyretin (ATTR) amyloidosis is responsible for the majority of cardiac amyloidosis (CA) cases and can be reliably diagnosed with bone scintigraphy and the visual Perugini score. We aimed to implement a quantification method of cardiac amyloid deposits in patients with suspected cardiac amyloidosis and to compare performance to visual scoring.

Methods and materials

136 patients received ^99mTc-DPD-bone scintigraphy including SPECT/CT of the thorax in case of suspicion of cardiac amyloidosis. Imaging phantom studies were performed to determine the scaling factor for standardized uptake value (SUV) quantification from SPECT/CT. Myocardial tracer uptake was quantified in a whole heart volume of interest.

Results

Forty-five patients were diagnos

SUBMITTER: Kessler L 

PROVIDER: S-EPMC9984322 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature