The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities.

ABSTRACT: Alteration of neuronal protein processing is often associated with neurological disorders and is highly dependent on cellular protein trafficking. A prime example is the amyloidogenic processing of amyloid precursor protein (APP) in intracellular vesicles, which plays a key role in age-related cognitive impairment. Most approaches to correct this altered processing aim to limit enzymatic activities that lead to toxic products, such as protein cleavage by β-secretase and the resulting amyloid β production. A viable alternative is to direct APP to cellular compartments where non-amyloidogenic mechanisms are favored. To this end, we exploited the molecular properties of the herpes simplex virus 1 (HSV-1) transport protein US9 to guide APP interaction with preferred endogenous targets. Specifi

SUBMITTER: Brandimarti R 

PROVIDER: S-EPMC9984340 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature