OPA1 drives macrophage metabolism and functional commitment via p65 signaling.

ABSTRACT: Macrophages are essential players for the host response against pathogens, regulation of inflammation and tissue regeneration. The wide range of macrophage functions rely on their heterogeneity and plasticity that enable a dynamic adaptation of their responses according to the surrounding environmental cues. Recent studies suggest that metabolism provides synergistic support for macrophage activation and elicitation of desirable immune responses; however, the metabolic pathways orchestrating macrophage activation are still under scrutiny. Optic atrophy 1 (OPA1) is a mitochondria-shaping protein controlling mitochondrial fusion, cristae biogenesis and respiration; clear evidence shows that the lack or dysfunctional activity of this protein triggers the accumulation of metabolic intermediate

SUBMITTER: Sanchez-Rodriguez R 

PROVIDER: S-EPMC9984365 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature