Variability in the substitution pattern of hydroxypropyl cellulose affects its physico-chemical properties

ABSTRACT: Hydroxypropyl cellulose (HPC) is a water-soluble polymer with many applications in food, pharmaceutical, medical, or paints industries. Past studies have reported that differences in functionality can occur between products of similar pharmaceutical grades. Understanding the origin of these differences is a major challenge for the industry. In this work, the structure and physico-chemical properties of several HPC samples of the same commercial grade were studied. Structural analysis by NMR and enzymatic hydrolysis were performed to study molar substitution and distribution of substituents along the polymer chain respectively. Water-polymer interactions, surface properties as well as rheological and thermal behavior were characterized to tentatively correlate them with the structure, and g

SUBMITTER: Cremer G 

PROVIDER: S-EPMC9984446 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature