Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy.

ABSTRACT: Potassium (K⁺) channels are robustly expressed during prenatal brain development, including in progenitor cells and migrating neurons, but their function is poorly understood. Here, we investigate the role of voltage-gated K⁺ channel KCNB1 (Kv2.1) in neocortical development. Neuronal migration of glutamatergic neurons was impaired in the neocortices of KCNB1 null mice. Migratory defects persisted into the adult brains, along with disrupted morphology and synaptic connectivity. Mice developed seizure phenotype, anxiety, and compulsive behavior. To determine whether defective KCNB1 can give rise to developmental channelopathy, we constructed Knock In (KI) mice, harboring the gene variant Kcnb1^R312H (R312H mice) found in children with developmental and epilept

SUBMITTER: Bortolami A 

PROVIDER: S-EPMC9984485 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature