Plasma metabolites with mechanistic and clinical links to the neurovascular disease cavernous angioma.

ABSTRACT:

Background

Cavernous angiomas (CAs) affect 0.5% of the population, predisposing to serious neurologic sequelae from brain bleeding. A leaky gut epithelium associated with a permissive gut microbiome, was identified in patients who develop CAs, favoring lipid polysaccharide producing bacterial species. Micro-ribonucleic acids along with plasma levels of proteins reflecting angiogenesis and inflammation were also previously correlated with CA and CA with symptomatic hemorrhage.

Methods

The plasma metabolome of CA patients and CA patients with symptomatic hemorrhage was assessed using liquid-chromatography mass spectrometry. Differential metabolites were identified using partial least squares-discriminant analysis (p < 0.05, FDR corrected). Interactions between these metabolite

SUBMITTER: Srinath A 

PROVIDER: S-EPMC9984539 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature