MSIMEP: Predicting microsatellite instability from microarray DNA methylation tumor profiles.

ABSTRACT: Deficiency in DNA MMR activity results in tumors with a hypermutator phenotype, termed microsatellite instability (MSI). Beyond its utility in Lynch syndrome screening algorithms, today MSI has gained importance as predictive biomarker for various anti-PD-1 therapies across many different tumor types. Over the past years, many computational methods have emerged to infer MSI using either DNA- or RNA-based approaches. Considering this together with the fact that MSI-high tumors frequently exhibit a hypermethylated phenotype, herein we developed and validated MSIMEP, a computational tool for predicting MSI status from microarray DNA methylation tumor profiles of colorectal cancer samples. We demonstrated that MSIMEP optimized and reduced models have high performance in predicting MSI in diffe

SUBMITTER: Santamarina-Garcia M 

PROVIDER: S-EPMC9984554 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature