PH-sensitive gold nanoclusters labeling with radiometallic nuclides for diagnosis and treatment of tumor.

ABSTRACT: The acidic microenvironment is one of the remarkable features of tumor and is also a reliable target for tumor theranostics. Ultrasmall gold nanoclusters (AuNCs) have good in vivo behaviors, such as non-retention in liver and spleen, renal clearance, and high tumor permeability, and held great potential for developing novel radiopharmaceuticals. Herein, we developed pH-sensitive ultrasmall gold nanoclusters by introducing quaternary ammonium group (TMA) or tertiary amine motifs (C6A) onto glutathione-coated AuNCs (TMA/GSH@AuNCs, C6A-GSH@AuNCs). Density functional theory simulation revealed that radiometal ⁸⁹Sr, ²²³Ra, ⁴⁴Sc, ⁹⁰Y, ¹⁷⁷Lu, ⁸⁹Zr, ^99mTc, ¹⁸⁸Re, ¹⁰⁶Rh, ⁶⁴Cu, ⁶

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC9984684 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature