Comparison of evoked potentials across four related developmental encephalopathies.

ABSTRACT:

Background

Developing biomarkers is a priority for drug development for all conditions, but vital in the rare neurodevelopmental disorders where sensitive outcome measures are lacking. We have previously demonstrated the feasibility and tracking of evoked potentials to disease severity in Rett syndrome and CDKL5 deficiency disorder. The aim of the current study is to characterize evoked potentials in two related developmental encephalopathies, MECP2 duplication syndrome and FOXG1 syndrome, and compare across all four groups to better understand the potential of these measures to serve as biomarkers of clinical severity for the developmental encephalopathies.

Methods

Visual and auditory evoked potentials were acquired from participants with MECP2 duplication syndrome and FOXG

SUBMITTER: Saby JN 

PROVIDER: S-EPMC9985257 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature