Anticancer properties of cannabidiol and Δ⁹-tetrahydrocannabinol and synergistic effects with gemcitabine and cisplatin in bladder cancer cell lines.

ABSTRACT:

Introduction

With the legalization of cannabis in multiple jurisdictions throughout the world, a larger proportion of the population consumes cannabis. Several studies have demonstrated anti-tumor effects of components present in cannabis in different models. Unfortunately, little is known about the potential anti-tumoral effects of cannabinoids in bladder cancer and how cannabinoids could potentially synergize with chemotherapeutic agents. Our study aims to identify whether a combination of cannabinoids, like cannabidiol and Δ⁹-tetrahydrocannabinol, with agents commonly used to treat bladder cancer, such as gemcitabine and cisplatin, can produce desirable synergistic effects. We also evaluated if co-treatment with different cannabinoids resulted in synergistic effects.<

SUBMITTER: Whynot EG 

PROVIDER: S-EPMC9985258 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature