Synaptic retrograde regulation of the PKA-induced SNAP-25 and Synapsin-1 phosphorylation.

ABSTRACT:

Background

Bidirectional communication between presynaptic and postsynaptic components contribute to the homeostasis of the synapse. In the neuromuscular synapse, the arrival of the nerve impulse at the presynaptic terminal triggers the molecular mechanisms associated with ACh release, which can be retrogradely regulated by the resulting muscle contraction. This retrograde regulation, however, has been poorly studied. At the neuromuscular junction (NMJ), protein kinase A (PKA) enhances neurotransmitter release, and the phosphorylation of the molecules of the release machinery including synaptosomal associated protein of 25 kDa (SNAP-25) and Synapsin-1 could be involved.

Methods

Accordingly, to study the effect of synaptic retrograde regulation of the PKA subunits and its act

SUBMITTER: Polishchuk A 

PROVIDER: S-EPMC9985302 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature