The Congenital and Acquired Mechanisms Implicated in the Etiology of Central Precocious Puberty.

ABSTRACT: The etiology of central precocious puberty (CPP) is multiple and heterogeneous, including congenital and acquired causes that can be associated with structural or functional brain alterations. All causes of CPP culminate in the premature pulsatile secretion of hypothalamic GnRH and, consequently, in the premature reactivation of hypothalamic-pituitary-gonadal axis. The activation of excitatory factors or suppression of inhibitory factors during childhood represent the 2 major mechanisms of CPP, revealing a delicate balance of these opposing neuronal pathways. Hypothalamic hamartoma (HH) is the most well-known congenital cause of CPP with central nervous system abnormalities. Several mechanisms by which hamartoma causes CPP have been proposed, including an anatomical connection to the anter

SUBMITTER: Brito VN 

PROVIDER: S-EPMC9985412 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature