Nasopharyngeal SARS-CoV-2 load and perinatal outcomes after maternal infection diagnosed close to delivery.

ABSTRACT:

Background

The occurrence of COVID-19 during the pregnancy can cause several negative maternal and neonatal outcomes. Nasopharyngeal viral load is associated with inflammatory markers and might influence the disease severity in non-pregnant patients, but there are no data about the relationship between viral load and perinatal outcomes in pregnant patients.

Objective

To investigate the hypothesis that nasopharyngeal SARS-CoV-2 load (estimated with real-time polymerase chain reaction delta cycle (ΔCt), measured in hospital clinical laboratories) is associated with perinatal outcomes, when COVID-19 is diagnosed in the third trimester of pregnancy.

Study design

International, retrospective, observational, multi-center, cohort study enrolling 390 women (393 neonates, thre

SUBMITTER: Vivanti AJ 

PROVIDER: S-EPMC9985537 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature