C-Type Lectin Receptor Mediated Modulation of T2 Immune Responses to Allergens.

ABSTRACT:

Purpose of review

Allergic diseases represent a major health problem of increasing prevalence worldwide. In allergy, dendritic cells (DCs) contribute to both the pathophysiology and the induction of healthy immune responses to the allergens. Different studies have reported that some common allergens contain glycans in their structure. C-type lectin receptors (CLRs) expressed by DCs recognize carbohydrate structures and are crucial in allergen uptake, presentation, and polarization of T cell responses. This review summarizes the recent literature regarding the role of CLRs in the regulation of type 2 immune responses to allergens.

Recent findings

In this review, we highlight the capacity of CLRs to recognize carbohydrates in common allergens triggering different signaling pat

SUBMITTER: Angelina A 

PROVIDER: S-EPMC9985561 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature