Midlife perceived stress is associated with cognitive decline across three decades.

ABSTRACT:

Background

Research indicates detrimental effects of stress on brain health and cognitive functioning, but population-based studies using comprehensive measures of cognitive decline is lacking. The present study examined the association of midlife perceived stress with cognitive decline from young adulthood to late midlife, controlling for early life circumstances, education and trait stress (neuroticism).

Methods

The sample consisted of 292 members of the Copenhagen Perinatal Cohort (1959-1961) with continued participation in two subsequent follow-up studies. Cognitive ability was assessed in young adulthood (mean age 27 years) and midlife (mean age 56 years) using the full Wechsler Adult Intelligence Scale (WAIS), and perceived stress was measured at midlife using the Perc

SUBMITTER: Christensen DS 

PROVIDER: S-EPMC9985854 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature