Leu72Met Polymorphism in Ghrelin Gene: A Potential Risk Factor for Hypertension in Type 2 Diabetes Patients.

ABSTRACT:

Objective

Ghrelin (GHRL) is known to be engaged in metabolic and cardiovascular processes. There is evidence suggesting its involvement in the regulation of blood pressure and hypertension. The purpose of this preliminary case-control study was to determine the involvement of the Leu72Met (rs696217) polymorphism in the GHRL gene in type 2 diabetes (T2DM).

Methods

The Leu72Met polymorphism was genotyped in 820 individuals with T2DM and 400 healthy subjects by the PCR-RFLP technique. The polymorphism distribution was first compared in those withT2DM and controls, then in subgroups of participants representing different clinical phenotypes.

Results

No significant association was identified between Leu72Met and T2DM. The distribution of polymorphism was analyzed in

SUBMITTER: Buraczynska M 

PROVIDER: S-EPMC9985889 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature