Technique for xenogeneic cross-circulation to support human donor lungs ex vivo.

ABSTRACT:

Background

Xenogeneic cross-circulation (XC) is an experimental method for ex vivo organ support and recovery that could expand the pool of donor lungs suitable for transplantation. The objective of this study was to establish and validate a standardized, reproducible, and broadly applicable technique for performing xenogeneic XC to support and recover injured human donor lungs ex vivo.

Methods

Human donor lungs (n = 9) declined for transplantation were procured, cannulated, and subjected to 24 hours of xenogeneic XC with anesthetized xeno-support swine (Yorkshire/Landrace) treated with standard immunosuppression (methylprednisolone, mycophenolate mofetil, tacrolimus) and complement-depleting cobra venom factor. Standard lung-protective perfusion and ventilation strategies,

SUBMITTER: Kelly Wu W 

PROVIDER: S-EPMC9985920 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature