Synthesis and crystal structures of new chiral 3-amino-2H-azirines and the Pd complex of one of them.

ABSTRACT: 3-Amino-2H-azirines are potentially versatile building blocks in heterocyclic and peptide synthesis. Three new 3-amino-2H-azirines have been synthesized as racemates or mixtures of diastereoisomers in cases where another chiral residue is incorporated as the exocyclic amine. The crystal structures of two of them, an approximately 1:1 diastereoisomeric mixture of (2R)- and (2S)-2-ethyl-3-[(2S)-2-(1-methoxy-1,1-diphenylmethyl)pyrrolidin-1-yl]-2-methyl-2H-azirine, C₂₃H₂₈N₂O, 11, and 2-benzyl-3-(N-methyl-N-phenylamino)-2-phenyl-2H-azirine, C₂₂H₂₀N₂, 12, and the third as its diastereoisomeric trans-PdCl₂ complex, trans-dichlorido[(2R)-2-ethyl-2-methyl-3-(X)-2H-azirine][(2S)-2-ethyl-2-methyl-3-(X)-2H-azirine]palladium(I

SUBMITTER: Linden A 

PROVIDER: S-EPMC9985946 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature