Impact of a bisphenol A, F, and S mixture and maternal care on the brain transcriptome of rat dams and pups.

ABSTRACT: Products containing BPA structural analog replacements have increased in response to growing public concern over adverse effects of BPA. Although humans are regularly exposed to a mixture of bisphenols, few studies have examined effects of prenatal exposure to BPA alternatives or bisphenol mixtures. In the present study, we investigate the effect of exposure to an environmentally-relevant, low-dose (150 ug/kg body weight per day) mixture of BPA, BPS, and BPF during gestation on the brain transcriptome in Long-Evans pups and dams using Tag RNA-sequencing. We also examined the association between dam licking and grooming, which also has enduring effects on pup neural development, and the transcriptomes. Associations between licking and grooming and the transcriptome were region-specific, wit

SUBMITTER: Lapp HE 

PROVIDER: S-EPMC9985957 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature