Dataset Information

Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β₂ to manipulate inflammatory responses.

ABSTRACT: Finely tuning mechanosensitive membrane proteins holds great potential in precisely controlling inflammatory responses. In addition to macroscopic force, mechanosensitive membrane proteins are reported to be sensitive to micro-nano forces. Integrin ^β₂, for example, might undergo a piconewton scale stretching force in the activation state. High-aspect-ratio nanotopographic structures were found to generate nN-scale biomechanical force. Together with the advantages of uniform and precisely tunable structural parameters, it is fascinating to develop low-aspect-ratio nanotopographic structures to generate micro-nano forces for finely modulating their conformations and the subsequent mechanoimmiune responses. In this study, low-aspect-ratio nanotopographic structures were

SUBMITTER: Guo Y

PROVIDER: S-EPMC9986042 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β₂ to manipulate inflammatory responses.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β2 to manipulate inflammatory responses.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β₂ to manipulate inflammatory responses.