Interference in point-of-care international normalized ratio monitoring in patients with lupus anticoagulant is correlated with anti-β2-glycoprotein I antibody titers.

ABSTRACT:

Background

Patients with antiphospholipid syndrome (APS) receive anticoagulant therapy with vitamin K antagonists (VKAs) to prevent recurrent thrombosis. VKA treatment requires strict monitoring with an international normalized ratio (INR). It is known that lupus anticoagulants (LAs) can lead to elevated INR results with point-of-care-testing (POCT) devices, which could result in inadequate adaptation of anticoagulant therapy.

Objective

To determine discrepancies between POCT-INR and laboratory-INR in patients who are LA-positive on VKA therapy.

Methods

Paired INR testing was performed with 1 POCT device (CoaguChek XS) and 2 laboratory assays (Owren and Quick method) in 33 patients with LA-positive APS on VKA in a single-center cross-sectional study. Patients were tes

SUBMITTER: Noordermeer T 

PROVIDER: S-EPMC9986099 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature