Determinants of successful immune tolerance induction in hemophilia A: systematic review and meta-analysis.

ABSTRACT:

Background

Immune tolerance induction (ITI) aims to eradicate anti-factor VIII (FVIII) antibodies (inhibitors) in persons with hemophilia A. However, this burdensome treatment fails in 10% to 40%. To estimate the chance of ITI success in clinical decision making, it is important to identify the predictors of ITI success.

Objectives

We performed a systematic review and meta-analysis to summarize the current evidence on determinants of ITI outcome in persons with hemophilia A.

Methods

A literature search was conducted to identify randomized controlled trials, cohort, or case-control studies reporting on the predictors for ITI outcome in persons with hemophilia A. The main outcome was ITI success. Methodological quality was assessed using an adapted Joanna Briggs Institu

SUBMITTER: Oomen I 

PROVIDER: S-EPMC9986104 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature