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The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the "hyperferritinemic syndromes".

ABSTRACT: A role for COVID19 in "hyperferritinemic syndromes" has been proposed based on its clinical and serological characteristics and its similarities with AOSD. To better understand the molecular pathways responsible of these similarities, we evaluated in the PBMCs of 4 active AOSD patients, 2 COVID19 patients with ARDS, and 2 HCs the expression of genes associated with iron metabolisms, with monocyte/macrophages activation, and finally with NETs formation.

SUBMITTER: Berardicurti O 

PROVIDER: S-EPMC9986116 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature

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The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the "hyperferritinemic syndromes".

Berardicurti Onorina O   Navarini Luca L   Vomero Marta M   Currado Damiano D   Biaggi Alice A   Marino Annalisa A   Bearzi Pietro P   Corberi Erika E   Rigon Amelia A   Arcarese Luisa L   Vadacca Marta M   Mattei Alessia A   Agrò Felice Eugenio FE   Incalzi Raffaele Antonelli RA   Sambuco Federica F   Travaglino Francesco F   Ruscitti Piero P   Cipriani Paola P   Giacomelli Roberto R  

Autoimmunity reviews 20230306 5

A role for COVID19 in "hyperferritinemic syndromes" has been proposed based on its clinical and serological characteristics and its similarities with AOSD. To better understand the molecular pathways responsible of these similarities, we evaluated in the PBMCs of 4 active AOSD patients, 2 COVID19 patients with ARDS, and 2 HCs the expression of genes associated with iron metabolisms, with monocyte/macrophages activation, and finally with NETs formation. ...[more]

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