Mitochondrial transplantation ameliorates hippocampal damage following status epilepticus.

ABSTRACT:

Background

Hippocampal damage caused by status epilepticus (SE) can bring about cognitive decline and emotional disorders, which are common clinical comorbidities in patients with epilepsy. It is therefore imperative to develop a novel therapeutic strategy for protecting hippocampal damage after SE. Mitochondrial dysfunction is one of contributing factors in epilepsy. Given the therapeutic benefits of mitochondrial replenishment by exogenous mitochondria, we hypothesized that transplantation of mitochondria would be capable of ameliorating hippocampal damage following SE.

Methods

Pilocarpine was used to induced SE in mice. SE-generated cognitive decline and emotional disorders were determined using novel object recognition, the tail suspension test, and the open field test.

SUBMITTER: Jia X 

PROVIDER: S-EPMC9986225 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature