MGluR5 in amygdala modulates fear memory generalization.

ABSTRACT:

Introduction

Fear memory generalization is regarded as the core characteristic of posttraumatic stress disorder (PTSD) development. However, the mechanism that contributes to the generalization of conditioned fear memory is still unclear. The generalization is generally considered to be a mismatch that occurs during memory consolidation.

Methods

Foot shocks and tones were given as unconditioned stress and conditioned stress, respectively for fear conditioning training. Immunofluorescence staining, western blotting and qPCR were performed to determine the expression of different genes in amygdala of mice after fear conditioning training. Cycloheximide was used as a protein synthesis inhibitor and 2-methyl-6-phenylethynyl-pyridine was injected for mGluR5 inhibition.

Results

SUBMITTER: Xuan SM 

PROVIDER: S-EPMC9986332 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature