Ontology highlight
ABSTRACT:
SUBMITTER: Schwarz A
PROVIDER: S-EPMC9986334 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Schwarz Agatha A Philippsen Rebecca R Piticchio Serena G SG Hartmann Jan N JN Häsler Robert R Rose-John Stefan S Schwarz Thomas T
Frontiers in immunology 20230220
The organ-specific microbiome plays a crucial role in tissue homeostasis, among other things by inducing regulatory T cells (Treg). This applies also to the skin and in this setting short chain fatty acids (SCFA) are relevant. It was demonstrated that topical application of SCFA controls the inflammatory response in the psoriasis-like imiquimod (IMQ)-induced murine skin inflammation model. Since SCFA signal <i>via</i> HCA2, a G-protein coupled receptor, and HCA2 expression is reduced in human le ...[more]