Development and Validation of a National US Achalasia Cohort: The Veterans Affairs Achalasia Cohort (VA-AC).

ABSTRACT:

Background & aims

Achalasia is an esophageal motility disorder associated with significant morbidity, yet achalasia-associated risk factors and outcomes are not well-characterized. Our aim was to establish a national cohort of individuals with achalasia, utilizing Veterans Health Administration (VHA) data.

Methods

We iteratively developed combinations of International Classification of Diseases and Current Procedural Terminology code algorithms to validate an approach for identifying achalasia cases. We assessed algorithm accuracy for achalasia diagnosis through manual chart review of candidate achalasia cases and candidate non-achalasia controls. The prespecified end point chosen to establish algorithm performance success was achieving a 1-sided 95% confidence lower bound f

SUBMITTER: Low EE 

PROVIDER: S-EPMC9986341 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature