Sex hormone-dependent and -independent regulation of serum BAFF and TNF in cohorts of transgender and cisgender men and women.

ABSTRACT:

Background

The risk of inflammatory diseases is sex-dependent, but it remains unknown whether this is due to the impact of sex hormones or sex chromosomes. Transgender individuals represent a unique cohort for studying the relative influence of endocrine and chromosomal factors. Here we compared serum levels of B-cell activating-factor (BAFF) and tumor necrosis factor (TNF) in transgender men (TM), transgender women (TW), cisgender women (CW) and cisgender men (CM).

Methods

BAFF and TNF were measured in the serum of 26 CW, 30 CM, 27 TM and 16 TW individuals. To determine the responsiveness of immune cells, TNF was measured in bacterial lipopolysaccharide (LPS)-treated peripheral leukocytes.

Results

BAFF was higher in CF (998 pg/mL) and TW (973 pg/mL) compared to CM (5

SUBMITTER: Tsatsanis C 

PROVIDER: S-EPMC9986405 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature