PPM1K-regulated impaired catabolism of branched-chain amino acids orchestrates polycystic ovary syndrome.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is one of the most common diseases with the coexistence of reproductive malfunction and metabolic disorders. Previous studies have found increased branched chain amino acid (BCAA) levels in women with PCOS. However, it remains unclear whether BCAA metabolism is causally associated with the risk of PCOS.

Methods

The changes of BCAA levels in the plasma and follicular fluids of PCOS women were detected. Mendelian randomization (MR) approaches were used to explore the potential causal association between BCAA levels and the risk of PCOS. The function of the gene coding the protein phosphatase Mg²⁺/Mn²⁺-dependent 1K (PPM1K) was further explored by using Ppm1k-deficient mouse model and PPM1K down-regulated human ov

SUBMITTER: Mu L 

PROVIDER: S-EPMC9986518 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature